Irisin limits amyloid-β buildup in Alzheimer's disease

Trends Endocrinol Metab. 2024 Feb;35(2):94-96. doi: 10.1016/j.tem.2023.11.006. Epub 2023 Dec 14.

Abstract

Mounting evidence suggests that physical exercise protects the brain against neurodegenerative disease. In a recent paper in Neuron, Kim et al. reported that the exercise-induced hormone irisin curbs amyloid-β buildup by promoting secretion of astrocyte-derived neprilysin. These findings may help explain the neuroprotection by irisin and exercise in Alzheimer's disease.

Keywords: Alzheimer’s disease; amyloid-β; astrocytes; irisin; physical exercise.

MeSH terms

  • Alzheimer Disease*
  • Amyloid beta-Peptides / pharmacology
  • Exercise
  • Fibronectins / pharmacology
  • Humans
  • Neurodegenerative Diseases*

Substances

  • Fibronectins
  • Amyloid beta-Peptides