The relative importance of N-oxidation and N-demethylation in the metabolism of trimethylamine in man

Toxicology. 1987 Feb;43(2):117-21. doi: 10.1016/0300-483x(87)90001-1.

Abstract

The metabolism of orally administered trimethylamine has been studied in 4 male volunteers at 2 dose levels. N-Oxidation was the major route of metabolism whilst N-demethylation was negligible and only significant at the higher dose level.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Dimethylamines / urine
  • Humans
  • Male
  • Methylamines / metabolism*
  • Methylation
  • Oxidation-Reduction

Substances

  • Dimethylamines
  • Methylamines
  • dimethylamine
  • trimethylamine