Emerging insights into the roles of ANGPTL8 beyond glucose and lipid metabolism

Huimin Ye; Qunchuan Zong; Huajie Zou; Ruixia Zhang

doi:10.3389/fphys.2023.1275485

Emerging insights into the roles of ANGPTL8 beyond glucose and lipid metabolism

Front Physiol. 2023 Dec 1:14:1275485. doi: 10.3389/fphys.2023.1275485. eCollection 2023.

Authors

Huimin Ye^#¹, Qunchuan Zong^#², Huajie Zou¹, Ruixia Zhang¹

Affiliations

¹ Department of Endocrinology and Metabolism, The Affiliated Hospital of Qinghai University, Xining, China.
² Department of Traumatology and Orthopaedics, The Affiliated Hospital of Qinghai University, Xining, China.

^# Contributed equally.

Abstract

Angiopoietin-like protein 8 (ANGPTL8) is a secreted protein predominantly expressed in liver and adipose tissue. ANGPTL8 modulates the clearance of triglycerides (TGs) by suppressing the activity of lipoprotein lipase (LPL) within the plasma. Previous studies found that circulating ANGPTL8 levels were significantly increased in metabolic disorder-related diseases, such as type 2 diabetes mellitus (T2DM), obesity, metabolic syndrome and nonalcoholic fatty liver disease (NAFLD). Whether ANGPTL8 has a direct pathogenic role in these diseases remains to be determined. In this review, we summarize the emerging roles of ANGPTL8 in the regulation of inflammation, tumours, circulatory system-related diseases, and ectopic lipid deposition, which may provide new insights into the diverse functions of ANGPTL8 in various diseases beyond its well-established functions in glucose and lipid metabolism.

Keywords: ANGPTL8; circulatory system; ectopic lipid deposition; inflammation; tumour.

Publication types

Review

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by the National Natural Science Foundation of China (82260172), the Natural Science Foundation of the Department of Science and Technology of Qinghai Province (2023-ZJ-959Q), and grants from the Qinghai University Youth Scientific Research Fund Project (2022-QYY-2).