Cellular microenvironment: a key for tuning mesenchymal stem cell senescence

Wenyang Sun; Jiacheng Lv; Shu Guo; Mengzhu Lv

doi:10.3389/fcell.2023.1323678

Cellular microenvironment: a key for tuning mesenchymal stem cell senescence

Front Cell Dev Biol. 2023 Dec 4:11:1323678. doi: 10.3389/fcell.2023.1323678. eCollection 2023.

Authors

Wenyang Sun¹, Jiacheng Lv¹, Shu Guo¹, Mengzhu Lv¹

Affiliation

¹ Department of Plastic Surgery, The First Hospital of China Medical University, Shenyang, Liaoning, China.

Abstract

Mesenchymal stem cells (MSCs) possess the ability to self-renew and differentiate into multiple cell types, making them highly suitable for use as seed cells in tissue engineering. These can be derived from various sources and have been found to play crucial roles in several physiological processes, such as tissue repair, immune regulation, and intercellular communication. However, the limited capacity for cell proliferation and the secretion of senescence-associated secreted phenotypes (SASPs) pose challenges for the clinical application of MSCs. In this review, we provide a comprehensive summary of the senescence characteristics of MSCs and examine the different features of cellular microenvironments studied thus far. Additionally, we discuss the mechanisms by which cellular microenvironments regulate the senescence process of MSCs, offering insights into preserving their functionality and enhancing their effectiveness.

Keywords: SASPs; cellular microenvironment; cellular senescence; mesenchymal stem cells; tissue engineering.

Publication types

Review

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This research was funded by National Natural Science Foundation of China (No. 51872332); and funded by Project of Liaoning Xingliao Talents Plan (XLYC2002103); and funded by The Doctoral Research Initiation of Foundation of Liaoning Province (No. 2022-BS-132).