1 Division of General Internal Medicine, Massachusetts General Hospital, Boston (Drs Ashburner, Singer, and Thorndike); Department of Medicine, Harvard Medical School, Boston (Drs Ashburner, Bhattacharya, Natarajan, Singer, and Thorndike); Cardiovascular Research Center and Center for Genomic Medicine, Massachusetts General Hospital, Boston (Ms Carmichael and Drs Bhattacharya and Natarajan); and Program in Medical and Population Genetics and the Cardiovascular Disease Initiative, Broad Institute of Harvard and MIT, Cambridge, Massachusetts (Drs Bhattacharya and Natarajan).