Sleep and rest-activity rhythms for women at different menopausal statuses: the role of mental health

Menopause. 2024 Feb 1;31(2):138-144. doi: 10.1097/GME.0000000000002297. Epub 2023 Dec 18.

Abstract

Objective: To examine how mental health interplays with menopausal status in relation to sleep patterns and rest-activity rhythms (RARs) among middle-aged women.

Methods: This cross-sectional study recruited 87 women aged 45 to 60 years from community and a gynecology clinic in Taiwan. Participants wore actigraphy devices for 7 days and were also assessed with self-reported questionnaires. Hierarchical regression was used to examine the effects of menopausal status and mental health on sleep and RARs.

Results: Perimenopausal and postmenopausal women had higher relative amplitude and interdaily stability of RARs than premenopausal women. There were no differences in actigraphy-based sleep parameters across menopausal statuses. There was no difference in depressive symptoms or loneliness across menopausal statuses. Higher levels of depressive symptoms were significantly associated with longer sleep latency ( β = 0.26, P = 0.022) and wake after sleep onset ( β = 0.28, P = 0.012), and lower sleep efficiency ( β = -0.30, P = 0.008) after adjusting for menopausal status and age. In addition, there was marginal significance of the positive association between loneliness and interdaily stability ( β = 0.18, P = 0.079). A moderating effect ( βmenopausal status*loneliness = -0.40, P = 0.025) showed that lonelier premenopausal women exhibited greater relative amplitude (RA) of rest-activity rhythms, but lonelier menopausal women had lower RA of RAR.

Conclusion: Mental health plays an important role for middle-aged women with different menopausal statuses in relation to sleep patterns and RARs.

MeSH terms

  • Actigraphy
  • Circadian Rhythm
  • Cross-Sectional Studies
  • Female
  • Humans
  • Menopause
  • Mental Health*
  • Middle Aged
  • Rest
  • Sleep*