Microglial APOE4: more is less and less is more

Mol Neurodegener. 2023 Dec 19;18(1):99. doi: 10.1186/s13024-023-00693-6.


Apolipoprotein E (APOE) is the single greatest genetic risk factor for late onset Alzheimer's disease (AD). Yet, the cell-specific effects of APOE on microglia function have remained unclear. Fortunately, two comprehensive new studies published in the latest issue of Nature Immunology have employed complementary gain-of-function and loss-of-function approaches to provide critical new insight into the impact of microglial APOE on AD pathogenesis.

Keywords: APOE3; APOE4; Alzheimer’s disease; Apolipoprotein E; Lgals3; Microglia; TGFβ.

Publication types

  • Editorial

MeSH terms

  • Alzheimer Disease* / genetics
  • Animals
  • Apolipoprotein E3 / genetics
  • Apolipoprotein E4* / genetics
  • Apolipoproteins E / genetics
  • Humans
  • Mice
  • Mice, Transgenic
  • Microglia


  • Apolipoprotein E4
  • Apolipoprotein E3
  • Apolipoproteins E