We report the case of a 70-year-old man with no significant medical history that presented with a rapid onset of generalized pink to livid papules. No enlarged lymph nodes were observed, and laboratory results revealed a low platelet count. A biopsy was performed, and histopathological examination revealed a cutaneous infiltration with a highly malignant blastoid neoplasm. Further examination performed by hematologists, including cytological analysis of a bone marrow puncture, confirmed acute myelogenous leukemia (AML). Molecular genetic testing revealed a mutation in the gene encoding nucleophosmin (NPM1), the most common genetic anomaly in adult AML. He was treated according to protocol with venetoclax and azacitidine, but he died 4 months post-induction due to infectious complications of febrile neutropenia and subsequent sepsis.