Efficacy of alitretinoin in the treatment of Darier disease: a case report

Acta Dermatovenerol Alp Pannonica Adriat. 2023 Dec;32(4):191-195.


Darier disease is a rare autosomal dominant genodermatosis that initially first presents in adolescence with scaly reddish brown keratotic papules and plaques with a seborrheic and intertriginous distribution. The absence of specific targeted medications complicates the treatment process, and managing resistant cases can prove challenging due to recurrent exacerbations that may result in serious complications such as secondary bacterial and viral infections. Treatments of choice include antiseptics, topical corticosteroids, and systemic retinoids, mainly acitretin and isotretinoin. We report the case of a female patient with Darier disease that was unsuccessfully treated with acitretin and isotretinoin but showed significant improvement with alitretinoin. Previous reports on the efficacy of alitretinoin in Darier disease are reviewed.

Publication types

  • Case Reports

MeSH terms

  • Acitretin / therapeutic use
  • Adolescent
  • Alitretinoin / therapeutic use
  • Darier Disease* / drug therapy
  • Dermatologic Agents* / therapeutic use
  • Female
  • Humans
  • Isotretinoin / therapeutic use


  • Alitretinoin
  • Acitretin
  • Isotretinoin
  • Dermatologic Agents