Plasmon-induced chemical reactions based on direct interactions between the plasmons of metal nanostructures and molecules have attracted increasing attention as a means of efficiently utilizing sunlight. In recent years, achievements in complex synthetic reactions as well as simple dissociation reactions of gaseous molecules using plasmons have been reported. However, recent research progress has revealed that multiple factors govern plasmon-induced chemical reactions. This perspective provides an overview of the key factors that influence plasmon-induced chemical reactions on metal surfaces and discusses the difficulty of controlling the reactions, which is caused by the entanglement of the key factors. A strategy for designing plasmonic metal catalysts to achieve the desired reactions is also discussed based on the current understanding, and directions for further research are provided.