Skin and ocular lesions were studied in murids Lemniscomys striatus L. infested by 2 isolates of Monanema spp, a rodent filaria with skin-dwelling microfilariae. Histologic examination disclosed microfilariae in lymphatic vessels. Penetration of microfilariae in extra-vascular tissues caused vascular changes, subacute inflammatory cells infiltration, granulomatous nodules and scarring lesions. These alterations corresponded to the successive stages of an inflammatory process. No correlation noted between tissular lesions, delay of filarial infestations and number of microfilariae in the "snip". The presence of lesions in one or several tissular areas demonstrated that extravascular escaping of microfilariae was not synchronous. Symptomatology of filariasis depended on the localization of the lesions. Similarities between the lesions noted in murids Lemniscomys striatus L. and those observed in man showed that the 2 isolates of Monanema spp. used in this study were very close to O. volvulus in the pathological domain. They might be considered as a valuable and reproducible experimental model.