Recruitment of PI4KIIIβ to the Golgi by ACBD3 is dependent on an upstream pathway of a SNARE complex and golgins

Mol Biol Cell. 2024 Feb 1;35(2):ar20. doi: 10.1091/mbc.E23-09-0376. Epub 2023 Dec 22.

Abstract

ACBD3 is a protein localised to the Golgi apparatus and recruits other proteins, such as PI4KIIIβ, to the Golgi. However, the mechanism through which ACBD3 itself is recruited to the Golgi is poorly understood. This study demonstrates there are two mechanisms for ACBD3 recruitment to the Golgi. First, we identified that an MWT374-376 motif in the unique region upstream of the GOLD domain in ACBD3 is essential for Golgi localization. Second, we use unbiased proteomics to demonstrate that ACBD3 interacts with SCFD1, a Sec1/Munc-18 (SM) protein, and a SNARE protein, SEC22B. CRISPR-KO of SCFD1 causes ACBD3 to become cytosolic. We also found that ACBD3 is redundantly recruited to the Golgi apparatus by two golgins: golgin-45 and giantin, which bind to ACBD3 through interaction with the MWT374-376 motif. Taken together, our results suggest that ACBD3 is recruited to the Golgi in a two-step sequential process, with the SCFD1-mediated interaction occurring upstream of the interaction with the golgins.

MeSH terms

  • Adaptor Proteins, Signal Transducing* / metabolism
  • Golgi Apparatus* / metabolism
  • Golgi Matrix Proteins / metabolism
  • Protein Binding
  • SNARE Proteins / metabolism

Substances

  • Golgi Matrix Proteins
  • Adaptor Proteins, Signal Transducing
  • SNARE Proteins