Magnetic resonance imaging of the midbrain in Parkinson's disease

Ann Neurol. 1986 Dec;20(6):744-7. doi: 10.1002/ana.410200618.


We have analyzed magnetic resonance images of the midbrain in patients with Parkinson's disease, and have found that there is a narrowing of the signal from the pars compacta of the substantia nigra relative to controls. The nature of the histological changes that may be responsible for this effect is discussed. Magnetic resonance imaging has the potential of becoming a useful diagnostic tool in the management of parkinsonism.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Humans
  • Magnetic Resonance Spectroscopy*
  • Mesencephalon / pathology*
  • Middle Aged
  • Parkinson Disease / pathology*