Reduction in paradoxical sleep after L-dopa administration in rats

Behav Neural Biol. 1986 Nov;46(3):249-56. doi: 10.1016/s0163-1047(86)90170-6.

Abstract

The EEG and EMG activity of two groups of rats (N = 8 each) was recorded during one experimental and 5 control days. On the experimental day, one group received 125.0 mg/kg L-dopa preceded by 50.0 mg/kg benserazide hydrochloride. The other group received 1.0 mg/kg haloperidol, immediately before the recording session. After L-dopa plus benserazide administration the total time and the number of episodes of paradoxical sleep and slow wave sleep decreased significantly compared to control sessions.

MeSH terms

  • Animals
  • Benserazide / pharmacology
  • Electroencephalography
  • Haloperidol / pharmacology
  • Injections, Intraperitoneal
  • Levodopa / pharmacology*
  • Male
  • Rats
  • Rats, Inbred Strains
  • Receptors, Dopamine / drug effects
  • Sleep Stages / drug effects
  • Sleep, REM / drug effects*
  • Sleep, REM / physiology

Substances

  • Receptors, Dopamine
  • Levodopa
  • Benserazide
  • Haloperidol