Abstract
Membranes prepared from the olfactory mucosa of the rat show a high level of adenylate cyclase activity. The activity increases up to 2-fold in the presence of physiologically relevant concentrations of odorants and is inhibited by Ca2+. The level of cyclase activity found is sufficient to explain the speed of olfactory transduction, which occurs on a time scale of tens of milliseconds.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetophenones / pharmacology*
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Adenylyl Cyclases / metabolism*
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Animals
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Calcium / pharmacology*
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Cell Membrane / drug effects
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Cell Membrane / enzymology
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Cyclohexane Monoterpenes
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Male
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Monoterpenes
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Olfactory Mucosa / drug effects
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Olfactory Mucosa / enzymology*
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Rats
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Rats, Inbred Strains
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Terpenes / pharmacology*
Substances
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Acetophenones
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Cyclohexane Monoterpenes
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Monoterpenes
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Terpenes
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carvone
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Adenylyl Cyclases
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acetophenone
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Calcium