Longitudinal Associations Between Mild Behavioral Impairment, Sleep Disturbance, and Progression to Dementia

Dinithi Mudalige; Dylan X Guan; Maryam Ghahremani; Zahinoor Ismail

doi:10.3233/ADR-230086

Longitudinal Associations Between Mild Behavioral Impairment, Sleep Disturbance, and Progression to Dementia

J Alzheimers Dis Rep. 2023 Dec 6;7(1):1323-1334. doi: 10.3233/ADR-230086. eCollection 2023.

Authors

Dinithi Mudalige¹, Dylan X Guan¹, Maryam Ghahremani², Zahinoor Ismail^{3

4}

Affiliations

¹ University of Calgary, Calgary, AB, Canada.
² Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada.
³ Department of Psychiatry, Department of Community Health Sciences, Department of Clinical Neurosciences, Hotchkiss Brain Institute, O'Brien Institute for Public Health, University of Calgary, Calgary, AB, Canada.
⁴ Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, UK.

Abstract

Background: Clinical guidelines recommend incorporating non-cognitive markers like mild behavioral impairment (MBI) and sleep disturbance (SD) into dementia screening to improve detection.

Objective: We investigated the longitudinal associations between MBI, SD, and incident dementia.

Methods: Participant data were from the National Alzheimer's Coordinating Center in the United States. MBI was derived from the Neuropsychiatric Inventory Questionnaire (NPI-Q) using a published algorithm. SD was determined using the NPI-Q nighttime behaviors item. Cox proportional hazard regressions with time-dependant variables for MBI, SD, and cognitive diagnosis were used to model associations between baseline 1) MBI and incident SD (n = 11,277); 2) SD and incident MBI (n = 10,535); 3) MBI with concurrent SD and incident dementia (n = 13,544); and 4) MBI without concurrent SD and incident dementia (n = 11,921). Models were adjusted for first-visit age, sex, education, cognitive diagnosis, race, and for multiple comparisons using the Benjamini-Hochberg method.

Results: The rate of developing SD was 3.1-fold higher in older adults with MBI at baseline compared to those without MBI (95% CI: 2.8-3.3). The rate of developing MBI was 1.5-fold higher in older adults with baseline SD than those without SD (95% CI: 1.3-1.8). The rate of developing dementia was 2.2-fold greater in older adults with both MBI and SD, as opposed to SD alone (95% CI:1.9-2.6).

Conclusions: There is a bidirectional relationship between MBI and SD. Older adults with SD develop dementia at higher rates when co-occurring with MBI. Future studies should explore the mechanisms underlying these relationships, and dementia screening may be improved by assessing for both MBI and SD.

Keywords: Alzheimer’s disease; dementia; longitudinal studies; neurobehavioral manifestations; sleep disorders.