The combination of holmium laser and ALA-PDT for Bowenoid Papulosis with diffuse large B-cell lymphoma

Photodiagnosis Photodyn Ther. 2024 Feb:45:103953. doi: 10.1016/j.pdpdt.2023.103953. Epub 2023 Dec 23.

Abstract

Bowenoid Papulosis (BP) is an anogenital pre-malignancy. BP with immunosuppression may recur, worsen, or possibly evolve into squamous cell carcinoma or Bowen's disease (BD), and it may also become resistant to conventional treatment. Here, we describe a complex case of BP together with BD and Diffuse Large B-Cell Lymphoma that was effectively treated with a holmium laser in conjunction with 5-Aminolevulinic Acid Photodynamic Therapy (ALA-PDT). The lesion totally vanished and the affected area remained intact with no recurrence at five years.

Keywords: ALA-PDT; Bowenoid Papulosis; Diffuse Large BCell Lymphoma; Holmium laser; Immunosuppression; Photodynamic Therapy.

Publication types

  • Case Reports

MeSH terms

  • Aminolevulinic Acid / therapeutic use
  • Bowen's Disease* / pathology
  • Carcinoma, Squamous Cell* / drug therapy
  • Humans
  • Lasers, Solid-State* / therapeutic use
  • Lymphoma, Large B-Cell, Diffuse* / drug therapy
  • Photochemotherapy* / methods
  • Photosensitizing Agents / therapeutic use
  • Precancerous Conditions* / drug therapy
  • Skin Neoplasms* / drug therapy

Substances

  • Aminolevulinic Acid
  • Photosensitizing Agents