Three new caryophyllene-type sesquiterpenoid glycosides from Biebersteinia heterostemon maxim

Qing Li; Wen-Jian Gu; Ya-Mei Zhang; Guo-Yue Zhong; Pu-Zhao Zhang

doi:10.1080/14786419.2023.2297257

Three new caryophyllene-type sesquiterpenoid glycosides from Biebersteinia heterostemon maxim

Nat Prod Res. 2023 Dec 25:1-7. doi: 10.1080/14786419.2023.2297257. Online ahead of print.

Authors

Qing Li¹, Wen-Jian Gu², Ya-Mei Zhang², Guo-Yue Zhong², Pu-Zhao Zhang¹

Affiliations

¹ Key Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Chinese Medicine, Nanchang, China.
² Research Center for Traditional Chinese Medicine Resources and Ethnic Minority Medicine, Jiangxi University of Chinese Medicine, Nanchang, China.

PMID: 38146225
DOI: 10.1080/14786419.2023.2297257

Abstract

Three new caryophyllene-type sesquiterpenoid glycosides were isolated from Biebersteinia heterostemon. Their structures were elucidated by comprehensive analysis of NMR and MS spectroscopic data. All the isolated compounds were evaluated for MCF-7/TAM cytotoxic activity. The results indicated that compound 1 was found to exhibit the weak cytotoxicity against MCF-7/TAM with the IC₅₀ value of 106.4 ± 0.04 μM.

Keywords: Biebersteinia heterostemon; Biebersteiniaceae; caryophyllene; sesquiterpenoid glycoside.