Prognostic value of lncRNA LINC01018 in prostate cancer by regulating miR-182-5p (The role of LINC01018 in prostate cancer)

Wentao Luo; Tingting Li; Qiong Song; Lixiao Zhang; Min Cao

doi:10.1080/15257770.2023.2298408

Prognostic value of lncRNA LINC01018 in prostate cancer by regulating miR-182-5p (The role of LINC01018 in prostate cancer)

Nucleosides Nucleotides Nucleic Acids. 2023 Dec 26:1-13. doi: 10.1080/15257770.2023.2298408. Online ahead of print.

Authors

Wentao Luo¹, Tingting Li¹, Qiong Song¹, Lixiao Zhang¹, Min Cao¹

Affiliation

¹ Department of Urology Andrology, Sinopharm Dongfeng General Hospital, Hubei University of Medicine, Shiyan, Hubei, China.

PMID: 38147366
DOI: 10.1080/15257770.2023.2298408

Abstract

LncRNAs are abnormally expressed in a variety of cancers and play unique roles in therapy. Based on this, the prognostic value of lncRNA LINC01018 in prostate cancer was discussed in this study. LINC01018 was underexpressed in prostate cancer tissues and cells, while miR-182-5p was elevated (***p < 0.001). Overexpression of LINC01018 may inhibit the progression of prostate cancer by targeting miR-182-5p. This study revealed that upregulated LINC01018 may prolong the overall survival of patients with prostate cancer (log-rank p = 0.042), and LINC01018 may become a prognostic biomarker for patients with prostate cancer, which brings a new direction for the treatment of patients.

Keywords: Prostate cancer; lncRNA LINC01018; miR-182-5p; overexpression; prognosis.