Avian Influenza A(H5N1) Neuraminidase Inhibition Antibodies in Healthy Adults after Exposure to Influenza A(H1N1)pdm09

Emerg Infect Dis. 2024 Jan;30(1):168-171. doi: 10.3201/eid3001.230756.

Abstract

We detected high titers of cross-reactive neuraminidase inhibition antibodies to influenza A(H5N1) virus clade 2.3.4.4b in 96.8% (61/63) of serum samples from healthy adults in Hong Kong in 2020. In contrast, antibodies at low titers were detected in 42% (21/50) of serum samples collected in 2009. Influenza A(H1N1)pdm09 and A(H5N1) titers were correlated.

Keywords: clade 2.3.4.4.b; cross-reactive antibody response; influenza; influenza A(H1N1)pdm09; influenza A(H5N1); neuraminidase inhibition antibody; pandemic risk assessment; respiratory infections; viruses.

MeSH terms

  • Adult
  • Animals
  • Antibodies, Viral
  • Humans
  • Influenza A Virus, H1N1 Subtype*
  • Influenza A Virus, H5N1 Subtype*
  • Influenza Vaccines*
  • Influenza in Birds*
  • Influenza, Human*
  • Neuraminidase

Substances

  • Neuraminidase
  • Antibodies, Viral
  • Influenza Vaccines