How New Developments in Pharmacology Receptor Theory Are Changing (Our Understanding of) Hypertension Therapy

Am J Hypertens. 2024 Mar 15;37(4):248-260. doi: 10.1093/ajh/hpad121.


Background: Many hypertension therapeutics were developed prior to major advances in drug receptor theory. Moreover, newer drugs may take advantage of some of the newly understood modalities of receptor function.

Goal: The goal of this review is to provide an up-to-date summary of drug receptor theory. This is followed by a discussion of the drug classes recognized for treating hypertension to which new concepts in receptor theory apply.

Results: We raise ideas for mechanisms of potential new antihypertensive drugs and whether they may take advantage of new theories in drug-receptor interaction.

Keywords: agonist; antagonist; blood pressure; constitutive activity; drug receptor theory; drug–receptor interaction; hypertension; inverse agonist.

Publication types

  • Review

MeSH terms

  • Antihypertensive Agents / therapeutic use
  • Drug Interactions
  • Humans
  • Hypertension* / drug therapy
  • Receptors, Drug / therapeutic use


  • Antihypertensive Agents
  • Receptors, Drug