Sustained complete remission in Richter's syndrome

Cancer. 1987 Mar 1;59(5):1036-9. doi: 10.1002/1097-0142(19870301)59:5<1036::aid-cncr2820590531>;2-d.


Richter's syndrome is the development of an aggressive diffuse lymphoma in chronic lymphatic leukemia (CLL) and is associated with a poor prognosis. A patient with CLL developed Richter's syndrome, which responded to intensive chemotherapy. Spontaneous regression of CLL in blood and marrow was observed at the onset of Richter's syndrome. The patient remained in complete remission from the lymphoma 4 years after the completion of treatment, and there was no evidence of CLL.

Publication types

  • Case Reports

MeSH terms

  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Cyclophosphamide / therapeutic use
  • Doxorubicin / therapeutic use
  • Humans
  • Karyotyping
  • Leukemia, Lymphoid / drug therapy*
  • Leukemia, Lymphoid / genetics
  • Leukemia, Lymphoid / pathology
  • Lymph Nodes / pathology
  • Male
  • Middle Aged
  • Prednisone / therapeutic use
  • Prognosis
  • Vincristine / therapeutic use


  • Vincristine
  • Doxorubicin
  • Cyclophosphamide
  • Prednisone

Supplementary concepts

  • CHOP protocol