Belantamab mafodotin is a humanized monoclonal antibody conjugate that was given accelerated approval for therapy of relapsed or refractory multiple myeloma in 2020 but was withdrawn in 2022 after failing to demonstrate a significant increase in survival compared to conventional therapies. Belantamab mafodotin has been linked to transient serum enzyme elevations during therapy and has been implicated in at least one case of fatal sinusoidal obstruction syndrome.