Effect of metformin on the risk of depression: A systematic review and meta-regression of observational studies

Yin Zhang; Vivien Kin-Yi Chan; Sandra Sau Man Chan; Esther Wai Yin Chan; Chi Ho Lee; Ian Ck Wong; Xue Li

doi:10.1016/j.ajp.2023.103894

Effect of metformin on the risk of depression: A systematic review and meta-regression of observational studies

Asian J Psychiatr. 2024 Feb:92:103894. doi: 10.1016/j.ajp.2023.103894. Epub 2023 Dec 23.

Authors

Yin Zhang¹, Vivien Kin-Yi Chan², Sandra Sau Man Chan³, Esther Wai Yin Chan⁴, Chi Ho Lee¹, Ian Ck Wong⁵, Xue Li⁶

Affiliations

¹ Department of Medicine, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region of China.
² Centre for Safe Medication Practice and Research, Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region of China.
³ Department of Psychiatry, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong Special Administrative Region of China.
⁴ Centre for Safe Medication Practice and Research, Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region of China; Laboratory of Data Discovery for Health (D24H), Hong Kong Science and Technology Park, Sha Tin, Hong Kong Special Administrative Region of China.
⁵ Centre for Safe Medication Practice and Research, Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region of China; Laboratory of Data Discovery for Health (D24H), Hong Kong Science and Technology Park, Sha Tin, Hong Kong Special Administrative Region of China; Research Department of Practice and Policy, UCL School of Pharmacy, London, United Kingdom; Aston School of Pharmacy, Aston University, Birmingham, United Kingdom.
⁶ Department of Medicine, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region of China; Centre for Safe Medication Practice and Research, Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region of China; Laboratory of Data Discovery for Health (D24H), Hong Kong Science and Technology Park, Sha Tin, Hong Kong Special Administrative Region of China. Electronic address: sxueli@hku.hk.

PMID: 38157715
DOI: 10.1016/j.ajp.2023.103894

No abstract available

Keywords: Asian population; Depression; Meta-regression; Metformin; Repurposing.

Publication types

Systematic Review
Letter

MeSH terms

Depression / drug therapy
Diabetes Mellitus, Type 2*
Humans
Hypoglycemic Agents / adverse effects
Metformin* / pharmacology
Metformin* / therapeutic use

Substances

Metformin
Hypoglycemic Agents