Viral RNA Is a Hub for Critical Host-Virus Interactions

Alfredo Castello; Louisa Iselin

doi:10.1007/978-3-031-40086-5_13

Viral RNA Is a Hub for Critical Host-Virus Interactions

Subcell Biochem. 2023:106:365-385. doi: 10.1007/978-3-031-40086-5_13.

Authors

Alfredo Castello¹, Louisa Iselin^{2

3}

Affiliations

¹ MRC University of Glasgow Centre for Virus Research, Glasgow, UK. alfredo.castello@glasgow.ac.uk.
² MRC University of Glasgow Centre for Virus Research, Glasgow, UK.
³ Nuffield Department of Medicine, Peter Medawar Building for Pathogen Research, University of Oxford, Oxford, UK.

PMID: 38159234
DOI: 10.1007/978-3-031-40086-5_13

Abstract

RNA is a central molecule in the life cycle of viruses, acting not only as messenger (m)RNA but also as a genome. Given these critical roles, it is not surprising that viral RNA is a hub for host-virus interactions. However, the interactome of viral RNAs remains largely unknown. This chapter discusses the importance of cellular RNA-binding proteins in virus infection and the emergent approaches developed to uncover and characterise them.

Keywords: Interferon-Stimulated Genes (ISGs); RNA; RNA Interactome Capture (RIC); RNA viruses; RNA-Binding Proteins (RBPs); Riboregulation.

MeSH terms

Host Microbial Interactions* / genetics
Host-Pathogen Interactions / genetics
RNA, Viral* / genetics
RNA, Viral* / metabolism
RNA-Binding Proteins / genetics
RNA-Binding Proteins / metabolism
Virus Replication

Substances

RNA, Viral
RNA-Binding Proteins