Colchicine suppression of local inflammation due to calcinosis in dermatomyositis and progressive systemic sclerosis

Clin Rheumatol. 1986 Dec;5(4):527-30.


Two girls, one with progressive systemic sclerosis and a second with dermatomyositis, developed calcinosis in the skin of the prepatellar area. Calcinosis was accompanied by local inflammation and skin ulceration. Oral colchicine therapy in a dosage of 1 mg per day was followed within two months by significant regression of local inflammation and healing of the skin ulcers.

Publication types

  • Case Reports

MeSH terms

  • Administration, Oral
  • Adolescent
  • Calcinosis / drug therapy*
  • Child
  • Colchicine / therapeutic use*
  • Dermatomyositis / drug therapy*
  • Female
  • Humans
  • Leg Ulcer / drug therapy*
  • Scleroderma, Systemic / drug therapy*


  • Colchicine