Correlation of renal function indicators and vascular damage in T2DM patients with normal renal function

Yue-Yang Zhang; Jing Gui; Bing-Xue Chen; Qin Wan

doi:10.3389/fendo.2023.1292397

Correlation of renal function indicators and vascular damage in T2DM patients with normal renal function

Front Endocrinol (Lausanne). 2023 Dec 18:14:1292397. doi: 10.3389/fendo.2023.1292397. eCollection 2023.

Authors

Yue-Yang Zhang^#^{1

2

3

4

5}, Jing Gui^#^{1

2

3

4

5}, Bing-Xue Chen⁶, Qin Wan^{1

2

3

4

5}

Affiliations

¹ Department of Endocrinology and Metabolism, the Affiliated Hospital of Southwest Medical University, Luzhou, China.
² Metabolic Vascular Disease Key Laboratory of Sichuan Province, Luzhou, China.
³ Sichuan Clinical Research Center for Diabetes and Metabolism, Luzhou, China.
⁴ Sichuan Clinical Research Center for Nephropathy, Luzhou, China.
⁵ Cardiovascular and Metabolic Diseases Key Laboratory of Luzhou, Luzhou, China.
⁶ Department of Medical Imaging, Southwest Medical University, Luzhou, China.

^# Contributed equally.

Abstract

Background: This study aimed to assess the correlation between renal function-related indices and vascular damages among patients with type 2 diabetes mellitus (T2DM) and normal renal function.

Methods: We screened a cohort of eligible patients with T2DM, ultimately including 826 individuals. Utilizing multifactorial logistic regression, we conducted an in-depth analysis to explore the potential associations between renal function-related indices-specifically BUN, Cr, ALB, ACR, and eGFR-and the incidence of diabetic vascular damage. Additionally, to comprehensively understand the relationships, we employed Spearman correlation analysis to assess the connections between these indicators and the occurrence of vascular damage.

Results: In this cross-sectional study of 532 patients with carotid atherosclerosis (CA), the prevalence of CA was positively correlated with Cr (53.1%, 72.3%, 68.0%, P<0.05) and negatively correlated with eGFR (71.6%, 68.5%, 53.1%, P<0.05). the higher the Cr, the higher the predominance ratio of CA (T1: reference; T2:OR. 2.166,95%CI:1.454,3.225; T3:OR:1.677, 95%CI:1.075, 2.616; P<0.05), along with an eGFR of 66.9% and 52.0% in terms of sensitivity and specificity, with a 95% CI of 0.562-0.644.

Conclusion: Within our experimental sample, a noteworthy observation emerged: Creatinine (Cr) exhibited a positive correlation with the prevalence of individuals affected by carotid atherosclerosis (CA), underscoring a potential connection between Cr levels and CA incidence. Conversely, the estimated Glomerular Filtration Rate (eGFR) demonstrated a negative correlation with the occurrence of CA, implying that lower eGFR values might be associated with an increased likelihood of CA development.

Keywords: Cr; carotid atherosclerosis; eGFR; renal function; type 2 diabetes mellitus.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Carotid Artery Diseases* / complications
Cross-Sectional Studies
Diabetes Mellitus, Type 2* / epidemiology
Glomerular Filtration Rate
Humans
Kidney

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. The Ministry of Science and Technology of China provided funding for this study through grants 2016YFC0901200.