Comparison of two benzodiazepines in the treatment of alcohol withdrawal: effects on symptoms and cognitive recovery

Drug Alcohol Depend. 1986 Dec;18(4):329-34. doi: 10.1016/0376-8716(86)90095-5.


Forty newly admitted alcohol-dependent patients were randomly allocated to equivalent 6-day regimes of either lorazepam or diazepam, to compare involvement in physical, emotional and cognitive state during the first 8 days in hospital. Diazepam provided a more comfortable withdrawal period and was associated with slightly better cognitive functioning on the eighth day.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Cognition / drug effects
  • Diazepam / therapeutic use*
  • Ethanol / adverse effects*
  • Female
  • Humans
  • Lorazepam / therapeutic use*
  • Male
  • Middle Aged
  • Psychological Tests
  • Substance Withdrawal Syndrome / drug therapy*
  • Substance Withdrawal Syndrome / psychology


  • Ethanol
  • Lorazepam
  • Diazepam