Regional spread of an atypical ESBL-producing Escherichia coli ST131H89 clone among different human and environmental reservoirs in Western Switzerland

Romain Martischang; Helena Seth-Smith; Tess D Verschuuren; Delphine Héquet; Nadia Gaïa; Patrice François; Ad C Fluit; Jan A J W Kluytmans; Salome N Seiffert; Evelina Tacconelli; Abdessalam Cherkaoui; Stephan Harbarth; Adrian Egli; Philipp Kohler

doi:10.1128/aac.00925-23

Regional spread of an atypical ESBL-producing Escherichia coli ST131H89 clone among different human and environmental reservoirs in Western Switzerland

Antimicrob Agents Chemother. 2024 Feb 7;68(2):e0092523. doi: 10.1128/aac.00925-23. Epub 2024 Jan 3.

Authors

Romain Martischang¹, Helena Seth-Smith^{2

3

4}, Tess D Verschuuren⁵, Delphine Héquet⁶, Nadia Gaïa⁷, Patrice François⁷, Ad C Fluit⁸, Jan A J W Kluytmans⁸, Salome N Seiffert⁹, Evelina Tacconelli^{10

11}, Abdessalam Cherkaoui¹², Stephan Harbarth¹, Adrian Egli^{2

3

4}, Philipp Kohler¹³

Affiliations

¹ Infection Control Programme and WHO Collaborating Centre, University of Geneva Hospitals and Faculty of Medicine, Geneva, Switzerland.
² Clinical Bacteriology and Mycology, University Hospital Basel, Basel, Switzerland.
³ Department of Biomedicine, Applied Microbiology Research, Basel University, Basel, Switzerland.
⁴ Institute of Medical Microbiology, University of Zurich, Zürich, Switzerland.
⁵ Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
⁶ Unité Cantonale Hygiène, Prévention et Contrôle de l'infection, Canton de Vaud, Switzerland.
⁷ Genomic Research Laboratory, Geneva University Hospitals, Geneva, Switzerland.
⁸ Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, the Netherlands.
⁹ Division of Human Microbiology, Centre for Laboratory Medicine, St. Gallen, Switzerland.
¹⁰ Department of Diagnostics and Public Health, Infectious Diseases, Verona University, Verona, Italy.
¹¹ Department of Internal Medicine Infectious Diseases, Tübingen University, Tübingen, Germany.
¹² Bacteriology Laboratory, Geneva University Hospitals, Geneva, Switzerland.
¹³ Division of Infectious Diseases and Hospital Epidemiology, Cantonal Hospital St Gallen, St Gallen, Switzerland.

Abstract

We describe the inter-regional spread of a novel ESBL-producing Escherichia coli subclone (ST131H89) in long-term care facility residents, general population, and environmental water sources in Western Switzerland between 2017 and 2020. The study highlights the importance of molecular surveillance for tracking emerging antibiotic-resistant pathogens in healthcare and community settings.

Keywords: Escherichia coli; ST131; antimicrobial resistance; long-term care facility; molecular epidemiology; surveillance.

MeSH terms

Anti-Bacterial Agents
Escherichia coli / genetics
Escherichia coli Infections* / epidemiology
Escherichia coli Proteins* / genetics
Humans
Molecular Epidemiology
Switzerland
beta-Lactamases

Substances

Escherichia coli Proteins
Anti-Bacterial Agents
beta-Lactamases

Abstract

MeSH terms

Substances

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