Pitrazepin: a central glycine and GABA antagonist

Eur J Pharmacol. 1986 Nov 19;131(2-3):311-3. doi: 10.1016/0014-2999(86)90590-x.

Abstract

In the spinal cord of the pentobarbitone-anaesthetised cat, microelectrophoretic pitrazepin reduced the inhibitory effects on neuronal firing of both glycine and GABA.

MeSH terms

  • Animals
  • Bicuculline / pharmacology
  • Cats
  • Dibenzazepines / pharmacology*
  • Electrophoresis
  • GABA Antagonists*
  • Glycine / antagonists & inhibitors*
  • Neurons / drug effects

Substances

  • Dibenzazepines
  • GABA Antagonists
  • pitrazepin
  • Glycine
  • Bicuculline