[Neuroblastoma in children. Clinical staging and management (author's transl)]

Klin Padiatr. 1979 Jul;191(4):347-55.
[Article in German]

Abstract

Sixty-four children with neuroblastoma stage I to III c are presented. The coordinated management utilizing surgical excision, irradiation (2--5.000 rad) in stage II and III and multiagent chemotherapy is described. Favorable sites were abdomen (30) and thorax (22). In ten cases the primary site was unknown. The prognosis is influenced by several factors: Patients under 1 year of age without evidence of bone or bone marrow metastases have a favorable outcome (13/15). Nearly all patients with lesions of bone or generalized tumor in bone and/or bone marrow (stage III b and III c) failed to attain long term disease free survival despite combination chemotherapy and the use of radiation therapy (33/34). No relation between histological or biochemical characteristics and prognosis could be found. Biochemical determinations however are useful as an index of response to treatment. Prognosis was independent from sex. A review of the literature and on attempt to improve the therapeutic efficancy in stage III are reported.

Publication types

  • English Abstract
  • Review

MeSH terms

  • Abdominal Neoplasms / diagnosis
  • Age Factors
  • Child, Preschool
  • Female
  • Humans
  • Infant
  • Male
  • Neoplasm Metastasis
  • Neoplasm Staging
  • Neuroblastoma* / diagnosis
  • Neuroblastoma* / drug therapy
  • Neuroblastoma* / radiotherapy
  • Neuroblastoma* / surgery
  • Prognosis
  • Thoracic Neoplasms / diagnosis