Immune system perturbations in patients with long COVID

Lucie Rodriguez; Petter Brodin

doi:10.1016/j.molmed.2023.12.008

Immune system perturbations in patients with long COVID

Trends Mol Med. 2024 Mar;30(3):200-201. doi: 10.1016/j.molmed.2023.12.008. Epub 2024 Jan 4.

Authors

Lucie Rodriguez¹, Petter Brodin²

Affiliations

¹ Department of Women's and Children's Health, Karolinska Institutet, 17165, Solna, Sweden.
² Department of Women's and Children's Health, Karolinska Institutet, 17165, Solna, Sweden; Department of Immunology and Inflammation, Imperial College London, London, UK; Medical Research Council London Institute of Medical Sciences (LMS), Imperial College Hammersmith Campus, London, UK. Electronic address: petter.brodin@ki.se.

PMID: 38177028
DOI: 10.1016/j.molmed.2023.12.008

Abstract

Klein et al. report multimodal analyses of immune cells, proteins, and physiological parameters in patients with long COVID (LC). At the group level, LC subjects exhibited elevated antibody responses to SARS-CoV-2, but also to herpes viruses, pointing to a general suppression of viral control mechanisms in LC.

Keywords: PACS; immunomonitoring; long COVID; systems immunology.

MeSH terms

COVID-19*
Humans
Immune System
Post-Acute COVID-19 Syndrome*
SARS-CoV-2