A rare goblet cell adenocarcinoma arising from Barrett's esophagus: the first reported case in the esophagus

J Pathol Transl Med. 2024 Mar;58(2):81-86. doi: 10.4132/jptm.2023.12.26. Epub 2024 Jan 8.


Goblet cell adenocarcinoma (GCA) is a rare and distinctive amphicrine tumor comprised of goblet-like mucinous cells and neuroendocrine cells. It is believed to originate from pluripotent stem cells located at the base of crypts. GCA predominantly arises from the appendix, with a few reported cases in extra-appendiceal locations such as the colorectum, small intestine, and stomach. In this case report, we present a unique instance of a 64-year-old male who initially received a diagnosis of neuroendocrine carcinoma in the distal esophagus based on biopsy but, following resection, was subsequently re-diagnosed with GCA arising from Barrett's esophagus.

Keywords: Extra-appendiceal; Goblet cell adenocarcinoma; Goblet cell carcinoid.