BrainBike peptidomimetic enables efficient transport of proteins across brain endothelium

RSC Chem Biol. 2023 Dec 11;5(1):7-11. doi: 10.1039/d3cb00194f. eCollection 2024 Jan 3.


Protein therapeutics cannot reach the brain in sufficient amounts because of their low permeability across the blood-brain barrier. Here we report a new family of bicyclic peptide shuttles, BrainBikes, capable of increasing transport of proteins, including antibody derivatives, in a human cell-based model of the blood-brain barrier.