Proteomics: A new dimension to decode small cell lung cancer

Haobin Chen; Benjamin J Drapkin; John D Minna

doi:10.1016/j.cell.2023.11.042

Proteomics: A new dimension to decode small cell lung cancer

Cell. 2024 Jan 4;187(1):14-16. doi: 10.1016/j.cell.2023.11.042.

Authors

Haobin Chen¹, Benjamin J Drapkin², John D Minna³

Affiliations

¹ Division of Oncology, Department of Medicine, Washington University in Saint Louis, St Louis, MO, USA. Electronic address: c.haobin@wustl.edu.
² Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, TX, USA. Electronic address: benjamin.drapkin@utsouthwestern.edu.
³ Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, TX, USA. Electronic address: john.minna@utsouthwestern.edu.

PMID: 38181738
DOI: 10.1016/j.cell.2023.11.042

Abstract

Small cell lung cancer (SCLC) is a recalcitrant malignancy. Conquering it will require deep insight into its biology. In this issue of Cell, Liu and colleagues describe proteomic and phosphoproteomic landscapes of resected SCLC tumors and illustrate the potential of this knowledge to identify new SCLC vulnerabilities.

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MeSH terms

Humans
Knowledge
Lung Neoplasms*
Proteomics
Small Cell Lung Carcinoma*