Disease applications of spinal cord stimulation: Chronic nonmalignant pain

Neurotherapeutics. 2024 Apr;21(3):e00314. doi: 10.1016/j.neurot.2023.e00314. Epub 2024 Jan 5.


Neuropathic pain is a chronic condition representing a significant burden for society. It is estimated 1 out of 10 people over the age of 30 that in the US have been diagnosed with neuropathic pain. Most of the available treatments for neuropathic pain have moderate efficacy over time which limit their use; therefore, other therapeutic approaches are needed for patients. Spinal cord stimulation is an established and cost-effective modality for treating severe chronic pain. In this article we will review the current approved indications for the use of spinal cord stimulation in the US and the novel therapeutic options which are now available using this therapy.

Keywords: Approved indications; Chronic pain; Neuromodulation; Neuropathy; Spinal Cord Stimulation.

Publication types

  • Review

MeSH terms

  • Chronic Pain* / therapy
  • Humans
  • Neuralgia / therapy
  • Pain Management* / methods
  • Spinal Cord Stimulation* / methods