Diagnostic or prognostic? Decoding the role of embryo selection on in vitro fertilization treatment outcomes

Haowen Zou; Rui Wang; Dean E Morbeck

doi:10.1016/j.fertnstert.2024.01.005

Diagnostic or prognostic? Decoding the role of embryo selection on in vitro fertilization treatment outcomes

Fertil Steril. 2024 May;121(5):730-736. doi: 10.1016/j.fertnstert.2024.01.005. Epub 2024 Jan 5.

Authors

Haowen Zou¹, Rui Wang¹, Dean E Morbeck²

Affiliations

¹ Department of Obstetrics and Gynaecology, Monash University, Melbourne, Victoria, Australia.
² Department of Obstetrics and Gynaecology, Monash University, Melbourne, Victoria, Australia; Principle, Morbeck Consulting Ltd, Auckland, New Zealand. Electronic address: deanmorbeckphd@gmail.com.

PMID: 38185198
DOI: 10.1016/j.fertnstert.2024.01.005

Abstract

In this review, we take a fresh look at embryo assessment and selection methods from the perspective of diagnosis and prognosis. On the basis of a systematic search in the literature, we examined the evidence on the prognostic value of different embryo assessment methods, including morphological assessment, blastocyst culture, time-lapse imaging, artificial intelligence, and preimplantation genetic testing for aneuploidy.

Keywords: Embryo; PGT-A; artificial intelligence; diagnosis; prognosis.

Publication types

Review

MeSH terms

Aneuploidy
Blastocyst
Embryo Culture Techniques* / methods
Embryo Transfer* / methods
Female
Fertilization in Vitro* / methods
Genetic Testing / methods
Humans
Infertility / diagnosis
Infertility / physiopathology
Infertility / therapy
Predictive Value of Tests
Pregnancy
Pregnancy Rate
Preimplantation Diagnosis* / methods
Prognosis
Time-Lapse Imaging / methods
Treatment Outcome