Deciphering the vital roles and mechanism of m5C modification on RNA in cancers

Lemei Zheng; Yumei Duan; Mengna Li; Jianxia Wei; Changning Xue; Shipeng Chen; Qingqing Wei; Faqing Tang; Wei Xiong; Ming Zhou; Hongyu Deng

Deciphering the vital roles and mechanism of m5C modification on RNA in cancers

Am J Cancer Res. 2023 Dec 15;13(12):6125-6146. eCollection 2023.

Authors

Lemei Zheng^{1

2

3}, Yumei Duan^{1

2

3}, Mengna Li^{1

2

3}, Jianxia Wei^{1

2

3}, Changning Xue^{1

2

3}, Shipeng Chen^{1

2

3}, Qingqing Wei^{1

2

3}, Faqing Tang^{1

4}, Wei Xiong^{1

2

3}, Ming Zhou^{1

2

3}, Hongyu Deng^{1

2

4}

Affiliations

¹ NHC Key Laboratory of Carcinogenesis, Hunan Key Laboratory of Oncotarget Gene, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University Changsha, Hunan, China.
² Cancer Research Institute and School of Basic Medical Sciences, Central South University Changsha, Hunan, China.
³ The Key Laboratory of Carcinogenesis and Cancer Invasion of The Chinese Ministry of Education, Central South University Changsha, Hunan, China.
⁴ Department of Clinical Laboratory, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University Changsha, Hunan, China.

PMID: 38187052
PMCID: PMC10767349

Abstract

5-methylcytosine (m5C modification) plays an essential role in tumors, which affects different types of RNA, the expression of downstream target genes, and downstream pathways, thus participating in the tumor process. However, the effect of m5C modification on RNA in tumors and the exact mechanism have not been systematically reviewed. Therefore, we reviewed the status and sites of m5C modification, as well as the expression pattern and biological functions of m5C regulators in tumors, and further summarized the effects and regulation mechanism of m5C modification on messenger RNA (mRNA), ribosomal RNA (rRNA), transfer RNA (tRNA), long non-coding RNA (lncRNA) and other RNA in tumors. Finally, we summed up the interaction network, potential application, and value in clinical diagnosis and treatment of tumors. Taken together, this review benefits revealing the mechanism of m5C modification in tumor progression and provides new strategies for tumor diagnosis and treatment.

Keywords: RNA; m5C modification; m5C regulator; target gene; tumor progression.

Publication types

Review