Sporadic Creutzfeldt-Jakob disease: Brain MRI lesion features from 2 cases reports

Hoang Dinh Au; Nguyen Thu Lan; Nguyen Thai Binh; Le Tuan Linh; Ma Mai Hien; Nguyen Minh Duc

doi:10.1016/j.radcr.2023.11.082

Sporadic Creutzfeldt-Jakob disease: Brain MRI lesion features from 2 cases reports

Radiol Case Rep. 2023 Dec 17;19(3):939-943. doi: 10.1016/j.radcr.2023.11.082. eCollection 2024 Mar.

Authors

Hoang Dinh Au¹, Nguyen Thu Lan¹, Nguyen Thai Binh¹, Le Tuan Linh¹, Ma Mai Hien^{2

3}, Nguyen Minh Duc⁴

Affiliations

¹ Diagnostic Imaging and Interventional Radiology Center, Hanoi Medical University Hospital, Ha Noi, Vietnam.
² Department of Radiology, Hanoi Medical University, Ha Noi, Vietnam.
³ Department of Radiology, Centre Hospitalière Annecy Genevois, Epagny Metz-Tessy, France.
⁴ Department of Radiology, Pham Ngoc Thach University of Medicine, Ho Chi Minh City, Vietnam.

Abstract

Sporadic Creutzfeldt-Jakob disease (sCJD) is an uncommon prion disease, also a fatal degenerative brain disorder. We aimed to illustrate 2 clinical cases, a 60-year-old female and a 57-year-old male, who came to the hospital due to rapidly progressive cognitive decline. A 1.5T brain MRI in both patients detected cortical and basal ganglia signal abnormalities with diffuse, asymmetrical features. The patient underwent electroencephalography and cerebrospinal fluid tests, which showed abnormal waves and a positive 14-3-3 protein test in the CSF samples of both patients. According to the 2018 US Centers for Disease Control and Prevention (CDC) diagnostic criteria, we finally diagnosed these patients with sCJD.

Keywords: Asymmetric cortical abnormality; Double hockey sign; Prion; Pulvinar sign; Sporadic Creutzfeldt-Jakob disease.

Publication types

Case Reports