Importance of showing HBsAg and HBcAg positivity in the liver for better aetiological definition of chronic liver disease

J Clin Pathol. 1987 Feb;40(2):167-71. doi: 10.1136/jcp.40.2.167.


Serum and tissue hepatitis B virus (HBV) markers were compared in 35 alcoholic and 23 non-alcoholic subjects affected by chronic liver disease. Seventeen point one per cent of alcoholic and 21.7% of non-alcoholic subjects had HBV tissue markers, but not serum markers, for this virus. It is therefore concluded that showing the presence of HBV tissue markers permits a better aetiological definition of hepatitis B surface antigen (HBsAg) negative chronic liver disease, both in alcoholic and non-alcoholic subjects.

Publication types

  • Comparative Study

MeSH terms

  • Chronic Disease
  • Female
  • Hepatitis B / complications
  • Hepatitis B / immunology*
  • Hepatitis B Core Antigens / analysis*
  • Hepatitis B Surface Antigens / analysis*
  • Humans
  • Liver / immunology*
  • Liver Diseases / etiology*
  • Liver Diseases / immunology
  • Liver Diseases, Alcoholic / etiology
  • Male
  • Middle Aged


  • Hepatitis B Core Antigens
  • Hepatitis B Surface Antigens