Diterpenoid Alkaloids from Delphinium liangshanense

Chem Biodivers. 2024 Jan 8:e202301923. doi: 10.1002/cbdv.202301923. Online ahead of print.


Two new C19-diterpenoid alkaloids of the lycoctonine-type (liangshanine A and liangshanine B) and nineteen known compounds (3-21) were isolated from the whole plant of Delphinium liangshanense W. T. Wang, and all the compounds were identified by different spectroscopic analyses, such as IR, HR-ESI-MS and NMR. All the compounds were isolated from this plant for the first time and tested for the anti-proliferation effects on MH7A and SF9 cells to figure their anti-rheumatoid arthritis and anti-insect activity, but none of them showed remarkable activity.

Keywords: C19-diterpenoid alkaloids; Delphinium liangshanense; Ranunculaceae; liangshanine A; liangshanine B.