Antacids and peptic ulcer--a reappraisal

Gut. 1979 Jun;20(6):538-45. doi: 10.1136/gut.20.6.538.


Antacids can reduce gastroduodenal acidity for long periods if taken in substantial quantities after food. Their healing effect on gastric ulcer is minimal, if present at all, and easily overwhelmed by the benefit obtained from admission to hospital. Intensive antacid therapy appears effective in healing duodenal ulcer and preventing haemorrhage from stress ulcer, and is comparable in these respects with cimetidine but with a higher incidence of side-effects. Clinical impression strongly suggests that antacids relieve pain in peptic ulcer but objective confirmation is lacking.

Publication types

  • Clinical Trial
  • Comparative Study
  • Review

MeSH terms

  • Aluminum Hydroxide / therapeutic use
  • Antacids / adverse effects
  • Antacids / therapeutic use*
  • Calcium Carbonate / therapeutic use
  • Cimetidine / therapeutic use
  • Clinical Trials as Topic
  • Double-Blind Method
  • Gastric Juice / metabolism
  • Humans
  • Hydrogen-Ion Concentration
  • Pain / drug therapy
  • Peptic Ulcer / drug therapy*
  • Peptic Ulcer Hemorrhage / prevention & control
  • Time Factors


  • Antacids
  • Aluminum Hydroxide
  • Cimetidine
  • Calcium Carbonate