Manipulation of metastasis and tumour growth by transfection with histocompatibility class I genes

J Immunogenet. Apr-Jun 1986;13(2-3):153-7. doi: 10.1111/j.1744-313x.1986.tb01096.x.

Abstract

Approximately 50% of fibrosarcomas induced with methylcholanthrene A were found to be defective in H-2 expression. In tumours which lack H-2K antigens, H-2 gene transfection was used to restore H-2K expression. The de novo expression of H-2K reduced tumorigenicity and abolished the formation of metastases in syngeneic mice. Expression of H-2K seems to render the tumour cells immunogenic and leads to effective recognition of the tumour cells by the host immune system.

MeSH terms

  • Animals
  • Fibrosarcoma / genetics
  • Fibrosarcoma / immunology*
  • Fibrosarcoma / pathology
  • H-2 Antigens / genetics*
  • Methylcholanthrene
  • Mice
  • Neoplasm Metastasis
  • Transfection*

Substances

  • H-2 Antigens
  • Methylcholanthrene