Prospective study design and data analysis in UK Biobank

Sci Transl Med. 2024 Jan 10;16(729):eadf4428. doi: 10.1126/scitranslmed.adf4428. Epub 2024 Jan 10.


Population-based prospective studies, such as UK Biobank, are valuable for generating and testing hypotheses about the potential causes of human disease. We describe how UK Biobank's study design, data access policies, and approaches to statistical analysis can help to minimize error and improve the interpretability of research findings, with implications for other population-based prospective studies being established worldwide.

Publication types

  • Review

MeSH terms

  • Biological Specimen Banks*
  • Data Analysis
  • Humans
  • Prospective Studies
  • Research Design
  • UK Biobank*