TIMely connections: APOE4, aging, and Alzheimer's

Immunity. 2024 Jan 9;57(1):8-10. doi: 10.1016/j.immuni.2023.12.015.

Abstract

How do APOE4 and aging, two of the strongest risk factors for late-onset Alzheimer's disease (AD), promote disease progression? In this issue of Immunity, Millet et al. examine microglia in AD mice bearing different APOE alleles at distinct ages and identify a conserved exhausted-like microglial state enriched in very elderly and APOE4 AD brains.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Aged
  • Aging / genetics
  • Alleles
  • Alzheimer Disease* / genetics
  • Animals
  • Apolipoprotein E4* / genetics
  • Brain
  • Humans
  • Mice

Substances

  • Apolipoprotein E4