Antifungal profile against Candida auris clinical isolates of tyroscherin and its new analog produced by the deep-sea-derived fungal strain Scedosporium apiospermum FKJ-0499

Haruki Azami; Yoshihiro Watanabe; Kazunari Sakai; Hiroki Nakahara; Hiroki Kojima; Toshiyuki Tokiwa; Kenichi Nonaka; Yoshihiko Noguchi; Yuriko Nagano; Tomoyasu Hirose; Toshiaki Sunazuka; Hidehito Matsui; Naoaki Arima; Kazutoyo Abe; Hideaki Hanaki; Masato Iwatsuki

doi:10.1038/s41429-023-00696-x

Antifungal profile against Candida auris clinical isolates of tyroscherin and its new analog produced by the deep-sea-derived fungal strain Scedosporium apiospermum FKJ-0499

J Antibiot (Tokyo). 2024 Mar;77(3):156-162. doi: 10.1038/s41429-023-00696-x. Epub 2024 Jan 11.

Authors

Haruki Azami^#¹, Yoshihiro Watanabe^#^{1

2}, Kazunari Sakai³, Hiroki Nakahara¹, Hiroki Kojima^{1

2}, Toshiyuki Tokiwa², Kenichi Nonaka^{1

2}, Yoshihiko Noguchi^{1

2}, Yuriko Nagano⁴, Tomoyasu Hirose^{1

2}, Toshiaki Sunazuka^{1

2}, Hidehito Matsui^{1

2}, Naoaki Arima³, Kazutoyo Abe³, Hideaki Hanaki^{1

2

3}, Masato Iwatsuki^{5

6}

Affiliations

¹ Graduate School of Infection Control Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan.
² Ōmura Satoshi Memorial Institute, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan.
³ Tokyo New Drug Research Laboratories, Pharmaceutical Business Unit, Kowa Company, Ltd., 2-17-43 Noguchicho, Higashimurayama, Tokyo, 189-0022, Japan.
⁴ Marine Biodiversity and Environmental Assessment Research Center, Research Institute for Global Change (RIGC), Japan Agency for Marine-Earth Science and Technology, 2-15 Natsushima-cho, Yokosuka, Kanagawa, 237-0061, Japan.
⁵ Graduate School of Infection Control Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan. iwatuki@lisci.kitasato-u.ac.jp.
⁶ Ōmura Satoshi Memorial Institute, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, 108-8641, Japan. iwatuki@lisci.kitasato-u.ac.jp.

^# Contributed equally.

PMID: 38200163
DOI: 10.1038/s41429-023-00696-x

Abstract

A new antifungal compound, named N-demethyltyroscherin (1), was discovered from the static fungal cultured material of Scedosporium apiospermum FKJ-0499 isolated from a deep-sea sediment sample together with a known compound, tyroscherin (2). The structure of 1 was elucidated as a new analog of 2 by MS and NMR analyses. The absolute configuration of 1 was determined by chemical derivatization. Both compounds showed potent in vitro antifungal activity against clinically isolated Candida auris strains, with MIC values ranging from 0.0625 to 4 µg ml^-1.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antifungal Agents* / pharmacology
Antifungal Agents* / therapeutic use
Candida auris
Epinephrine / analogs & derivatives*
Fatty Alcohols*
Fungi
Microbial Sensitivity Tests
Scedosporium*

Substances

Antifungal Agents
tyroscherin
Epinephrine
Fatty Alcohols

Abstract

Publication types

MeSH terms

Substances

Grants and funding