Ameliorative Effect of Ginsenoside Rg6 in Periodontal Tissue Inflammation and Recovering Damaged Alveolar Bone

Molecules. 2023 Dec 20;29(1):46. doi: 10.3390/molecules29010046.

Abstract

Periodontal disease is a chronic disease with a high prevalence, and in order to secure natural materials to prevent oral diseases, new materials that protect periodontal tissue from inflammation are being sought. Genes were identified using real-time quantitative polymerase chain reaction (RT-qPCR), and proteins were confirmed using Western blot. Dichlorodihydrofluorescein diacetate (DCF-DA) analysis was used, and the antibacterial effects were confirmed through Minimum Inhibitory Concentration (MIC) and Minimal Bactericidal Concentration (MBC) analysis. To confirm this effect in vivo, Sprague-Dawley rats, in which periodontitis was induced using ligation or Lipopolysaccharide of Porphyromonas gingivalis (PG-LPS), were used. In vitro experiments using human periodontal ligament (HPDL) cells stimulated with PG-LPS showed that Ginsenoside Rg6 (G-Rg6) had anti-inflammatory, antibacterial, antioxidant, and osteoblast differentiation properties. In vivo, G-Rg6 was effective in Sprague-Dawley rats in which periodontitis was induced using ligation or PG-LPS. Therefore, Ginsenoside Rg6 shows potential effectiveness in alleviating periodontitis.

Keywords: Porphyromonas gingivalis; anti-inflammatory; antibacterial effects; antioxidant; ginsenoside Rg6; osteoblast differentiation; periodontitis.

MeSH terms

  • Animals
  • Anti-Bacterial Agents
  • Ginsenosides*
  • Humans
  • Inflammation / drug therapy
  • Lipopolysaccharides* / toxicity
  • Periodontitis* / drug therapy
  • Porphyromonas gingivalis
  • Rats
  • Rats, Sprague-Dawley

Substances

  • ginsenoside Rg6
  • Lipopolysaccharides
  • Anti-Bacterial Agents
  • Ginsenosides