In attempts to enhance natural products as therapeutic agents, fluorination has emerged as a new tool for synthetic biologists and chemists. In recent articles published in Nature Chem. and Nature Chem. Bio., Grininger, Chang, and co-workers leveraged their expertise in engineering polyketide biosynthesis to incorporate fluorine into polyketide scaffolds.
Keywords: Biocatalysis; Biosynthesis; Chemical Biology; Drug Discovery; Fluorine; Halogenation; Macrolides; Polyketides; Secondary Metabolites; Synthetic Biology.