Targeted Enzyme Modifications Enable Regioselective Biosynthesis of Fluorinated Polyketides

Chem Catal. 2022 Oct 20;2(10):2440-2443. doi: 10.1016/j.checat.2022.09.042.


In attempts to enhance natural products as therapeutic agents, fluorination has emerged as a new tool for synthetic biologists and chemists. In recent articles published in Nature Chem. and Nature Chem. Bio., Grininger, Chang, and co-workers leveraged their expertise in engineering polyketide biosynthesis to incorporate fluorine into polyketide scaffolds.

Keywords: Biocatalysis; Biosynthesis; Chemical Biology; Drug Discovery; Fluorine; Halogenation; Macrolides; Polyketides; Secondary Metabolites; Synthetic Biology.