Evaluation of Tamsulosin 0.4 mg versus 0.8 mg in management of lower urinary tract symptoms due to benign prostatic enlargement

Int Urol Nephrol. 2024 Jun;56(6):1811-1816. doi: 10.1007/s11255-023-03912-7. Epub 2024 Jan 14.

Abstract

Purpose: To compare the efficacy and the safety of Tamsulosin 0.4 mg/day and 0.8 mg/day in patients suffering from lower urinary tract symptoms due to benign prostatic obstruction.

Patients and methods: A prospective interventional, double-blinded, controlled study was carried out on 93 patients who met the criteria and divided randomly into two groups: group A for Tamsulosin 0.4 mg/day and group B for Tamsulosin 0.8 mg/day. International prostate symptom score, post void residual urine volume, and maximum flow rate of urine were assessed before and after 4 weeks of treatment.

Results: Both study groups showed a significant reduction in storage sub-score but only frequency was significantly reduced in group B (P < 0.001). On the other hand, Tamsulosin 0.8 mg was superior to Tamsulosin 0.4 mg regarding voiding sub-score except for straining (P = 0.325). Accordingly, the total international prostate symptom score was significantly improved in group B versus group A (P < 0.001). Furthermore, maximum flow rate and post-void residual urine volume were notably improved in Group B as compared to Group A (P < 0.001). Of all adverse events only dizziness was noted to be statistically significant in Group B versus Group A (P < 0.001).

Conclusion: Tamsulosin 0.8 mg has shown better outcomes in treating patients who suffer from lower urinary tract symptoms due to benign prostatic enlargement than Tamsulosin 0.4 mg, and besides that, it is well tolerated.

Trial registration number: M S 292/2020, SID: 373, date: 22/4/2020.

Keywords: Benign prostatic enlargement; Lower urinary tract symptoms; Maximum flow rate; Tamsulosin.

Publication types

  • Randomized Controlled Trial
  • Comparative Study

MeSH terms

  • Adrenergic alpha-1 Receptor Antagonists* / administration & dosage
  • Adrenergic alpha-1 Receptor Antagonists* / therapeutic use
  • Aged
  • Double-Blind Method
  • Humans
  • Lower Urinary Tract Symptoms* / drug therapy
  • Lower Urinary Tract Symptoms* / etiology
  • Male
  • Middle Aged
  • Prospective Studies
  • Prostatic Hyperplasia* / complications
  • Tamsulosin* / administration & dosage
  • Tamsulosin* / therapeutic use
  • Treatment Outcome

Substances

  • Tamsulosin
  • Adrenergic alpha-1 Receptor Antagonists